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ELDEPRYL (SELEGILINE HCL) TABLETS: INFORMATION FOR PATIENTS

Patients should be advised of the possible need to reduce levodopa dosage after the initiation of Eldepryl (Selegiline) tablets therapy.

Patients (or their families if the patient is incompetent) should be advised not to exceed the daily recommended dose of 10 mg. The risk of using higher daily doses of selegiline should be explained, and a brief description of the "cheese reaction" provided. Rare hypertensive reactions with selegiline at recommended doses associated with dietary influences have been reported.

Consequently, it may be useful to inform patients (or their families) about the signs and symptoms associated with MAOI induced hypertensive reactions. In particular, patients should be urged to report, immediately, any severe headache or other atypical or unusual symptoms not previously experienced.

There have been reports of patients experiencing intense urges to gamble, increased sexual urges, and other intense urges and the inability to control these urges while taking one or more of the medications that increase central dopaminergic tone, that are generally used for the treatment of Parkinson's disease, including Eldepryl (Selegiline HCl). Although it is not proven that the medications caused these events, these urges were reported to have stopped in some cases when the dose was reduced or the medication was stopped. Prescribers should ask patients about the development of new or increased gambling urges, sexual urges or other urges while being treated with Eldepryl. Patients should inform their physician if they experience new or increased gambling urges, increased sexual urges or other intense urges while taking Eldepryl. Physicians should consider dose reduction or stopping the medication if a patient develops such urges while taking Eldepryl.

Manufactured and distributed by Orion Corporation and Somerset Pharmaceuticals companies and their divisions.

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