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Selegiline or L-Deprenyl (trade names include Eldepryl; Emsam; Deprenyl; Anipryl; Egibren; Jumex; Jumexil; Moverdin; Selegos; Selgian; Selgin; Zelapar) is an antiparkinsonian drug from monoamine oxidase type B (MAO-B) inhibitors pharmacological group. This medication is used to treat symptoms of Parkinson's disease, parkinsonism, shaking palsy, paralysis agitans, such as dementia in Alzheimer's disease, shakiness (tremor), muscle stiffness, loss of normal movement, sudden switching between normal movement and stiffness, other movement disorders. This is a cognitive enhancing smart anti aging drug that improves brain functions, cognitive actions, concentration, the range of motion and ability to walk, dress, exercise. Selegiline works by increasing and extending the effects of levodopa, and helping to slow the progress of Parkinson's disease. Deprenyl is usually used in combination with other antiparkinson medications (e.g., levodopa, carbidopa).
Emsam (Selegiline in the form of transdermal patch) is prescribed for the therapy of depression and major depressive disorder.
This medication is also indicated to treat the symptoms of Cushing's disease and cognitive dysfunction in veterinary medicine for dogs, pets and animals.
Selegiline was tested and studied for the treatment of attention deficit hyperactivity disorder (ADHD); to stop smoking tobacco or cannabis.
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Selegiline Hydrochloride medications
Eldepryl prescribing information
Eldepryl patient information
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General information about Selegiline (Deprenyl, Eldepryl, Emsam):
Pharmacological and medical categories for selegiline:
Anti aging drugs
Pharmaceutical drugs for the treatment of Parkinson's disease
Central nervous system agents
Dopaminergic antiparkinsonism agents
Meds to treat ADHD
Monoamine oxidase B (MAO-B) inhibitors
Stop smoking pills
Veterinary medications; pet meds
The Anatomical Therapeutic Chemical (ATC) classification system selegiline codes:
N - Nervous system
N04 - Anti-parkinson drugs
N04B - Dopaminergic agents
N04BD - Monoamine oxidase B inhibitors
N04BD01 - Selegiline
Selegiline in The International Statistical Classification of Diseases and Related Health Problems (ICD-10, World Health Organization) codes:
Cushing's syndrome - E24
Dementia in Alzheimer's disease ( G30.-+ ) - F00*
Cannabis related disorders - F12
Major depressive disorder, single episode - F32
Major depressive disorder, recurrent - F33
Attention-deficit hyperactivity disorders - F90
Parkinson's disease - G20
Other specified degenerative diseases of nervous system - G31.8
Mild cognitive impairment, so stated - G31.84
Tobacco abuse counseling - Z71.6
Pregnancy and breastfeeding categories for Selegiline (Eldepryl, Deprenyl):
B2 - Australia
C - United States (Risk cannot be ruled out)
Salts and other selegiline forms used as active pharmaceutical ingredients (API):
Synonyms of selegiline, international and chemical names:
Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-, (R)-
Best known selegiline brands, generics, trade names in various countries:
Anipryl - Pfizer; Zoetis
Cognitive - Ebewe Pharma; Ever Pharma
Deprenyl - Orion Pharma; Sanofi-Aventis
Deprilan - Biosintetica Laboratorios
Egibren - Chiesi
Eldepryl - Orion Corporation
Emsam - Mylan
Jumex - Sanofi-Aventis; Armstrong Laboratorios de Mexico; Chiesi; Chinoin Pharmaceutical and Chemical Works; Dexxon; DKSH; IDS Group; IVAX; Lexapharm; Metro Drug Distribution; Novartis; Paranova; The Glory Medicina; Torrent Pharmaceuticals; Zuellig Pharma
Jumexil - Farmalab Industrias Quimicas e Farmaceuticas
Moverdin - Kocak Farma Ilac
Niar - Abbott; Knoll
Otrasel - Cephalon; Lafon Laboratoires
Plurimen - Orion Pharma; Asta Medica; Viatris
Selegilin - AbZ-Pharma; Azupharma; CT-Arzneimittel; Mepha; Ratiopharm
Selegilina - Davur Laboratorios; Generis Farmaceutica
Selegiline - Alphapharm; Apotex; Biogaran; Generics UK; Mylan; Sandoz; Teva
Selegos - Medochemie; Britton Distributions; Derek Marketing; Komedic; Star Medical Supplies
Selerin - Cipla; Protec
Selgian - Ceva Animal Health; Biokema; Ceva Sante Animale; Sanofi-Aventis
Selgin - Intas Pharmaceuticals
Tonus - Acapi
Xilopar - Teva; Cephalon; Elan Pharmaceuticals; Esteve; Segix Italia
Zelapar - Teva; B & S Healthcare; Cardinal Health; Cephalon; Elan Pharmaceuticals; Lexon UK; Servipharm; Star Pharmaceuticals; Valeant Pharmaceuticals; Zeneus Pharma
Some other medications in Deprenyl, Eldepryl and Emsam (Selegiline) pharmacological classes:
Almirid (Dihydroergocryptine Mesylate)
Sinemet (Carbidopa; Levodopa)
Stalevo (Carbidopa; Entacapone; Levodopa)
SELEGILINE (DEPRENYL; ELDEPRYL) MEDICATION GUIDE
What is Selegiline, generic Eldepryl and Deprenyl?
Selegiline prevents the breakdown of a chemical in your brain called dopamine. Low levels of this chemical are associated with Parkinson's disease.
Eldepryl is used together with other medicines to treat symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control. Selegiline oral is also used to treat similar muscle symptoms when they are caused by certain medicines, including chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), and others.
This medication may also be used for purposes other than those listed in this medication guide.
Selegiline (Eldepryl; Deprenyl) indications and usage
Eldepryl and Deprenyl (Selegiline HCl) is indicated as an adjunct in the management of Parkinsonian patients being treated with levodopa/carbidopa who exhibit deterioration in the quality of their response to this therapy. There is no evidence from controlled studies that selegiline has any beneficial effect in the absence of concurrent levodopa therapy.
Evidence supporting this claim was obtained in randomized controlled clinical investigations that compared the effects of added selegiline or placebo in patients receiving levodopa/carbidopa. Selegiline was significantly superior to placebo on all three principal outcome measures employed: change from baseline in daily levodopa/carbidopa dose, the amount of 'off' time, and patient self-rating of treatment success. Beneficial effects were also observed on other measures of treatment success (e.g., measures of reduced end of dose akinesia, decreased tremor and sialorrhea, improved speech and dressing ability and improved overall disability as assessed by walking and comparison to previous state).
Side effects of selegiline
The common side effects reported with Eldepryl are increased tremor, chorea, loss of balance, restlessness, blepharospasm, increased bradykinesia, tardive dyskinesia, dystonic symptoms, dyskinesia, involuntary movements, freezing, festination, hallucinations, dizziness, confusion, anxiety, depression, drowsiness, behavior/mood change, headache, back pain, leg pain, tinnitus, migraine, supraorbital pain, throat burning, orthostatic hypotension, hypertension, arrhythmia, palpitations, new or increased angina pectoris, nausea/vomiting, constipation, weight loss, anorexia, poor appetite, dysphagia and diarrhea.
Guidelines before using Selegiline Hydrochloride (Deprenyl; Eldepryl) generic
Do not use Eldepryl if you are also taking meperidine (Demerol).
Before using this medication, tell your doctor if you have heart disease, seizures, or dizzy spells.
If you need to have surgery, tell the surgeon that you are using selegiline. You may need to briefly stop using the medicine before your surgery.
FDA pregnancy category C. This drug may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether selegiline hydrochloride passes into breast milk or if it could harm a nursing baby. Do not take Eldepryl without telling your doctor if you are breast-feeding a baby.
What are the common dosages of this medication?
Deprenyl and Eldepryl (Selegiline Hydrochloride) is intended for administration to Parkinsonian patients receiving levodopa/carbidopa therapy who demonstrate a deteriorating response to this treatment. The recommended regimen for the administration of Eldepryl (Selegiline HCl) is 10 mg per day administered as divided doses of 5 mg each taken at breakfast and lunch. There is no evidence that additional benefit will be obtained from the administration of higher doses. Moreover, higher doses should ordinarily be avoided because of the increased risk of side effects.
After two to three days of selegiline treatment, an attempt may be made to reduce the dose of levodopa/carbidopa. A reduction of 10 to 30% was achieved with the typical participant in the domestic placebo controlled trials who was assigned to selegiline treatment. Further reductions of levodopa/carbidopa may be possible during continued selegiline therapy.
How should I take Selegiline Hydrochloride (Eldepryl; Deprenyl)?
Take this medicine by mouth with a glass of water. Take your doses at regular intervals. Do not take selegiline more often than directed. Do not stop taking except on the advice of your doctor or health care professional.
Talk to your pediatrician regarding the use of this drug in children. Special care may be needed.
Note: This medication is only for you. Do not share this medicine with others.
What if I miss a dose?
If you miss a dose of selegiline, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What happens if I overdose?
If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
Symptoms of selegiline overdose may include excitement, irritability, nervousness, insomnia, dizziness, severe headache, hallucinations, sweating, light-headedness, fainting, or seizures.
What may interact with this medicine?
Do not use Eldepryl or Deprenyl if you are also taking meperidine (Demerol).
Before using selegiline, tell your doctor if you are using any of the following drugs:
antidepressants such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), paroxetine (Paxil), or sertraline (Zoloft);
antidepressants such as amitriptyline (Elavil), nortriptyline (Pamelor), desipramine (Norpramin), or imipramine (Tofranil);
St. John's wort;
carbamazepine (Tegretol) or oxcarbazepine (Trileptal);
cold or cough medicine; or
diet pills or stimulants.
If you are using any of these drugs, you may not be able to take selegiline, or you may need dosage adjustments or special tests during treatment.
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Where should I keep selegiline tablets or capsules?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
What is the difference between brand and generic Selegiline (Eldepryl, Deprenyl)?
Brand and generic Eldepryl in oral capsules and tablets contains "selegiline hydrochloride" as the active ingredient and hence the mechanism of action is the same. The difference between brand and generic forms are packaging, pricing and the brand name. Generic variants are priced cheaper because there are no brand names associated with it as well as no expenses towards research and development. You can buy cheap selegiline medicine when it is sold as a generic variant.
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Here is a list of some medications containing "Selegiline" as a main active pharmaceutical ingredient (API) of selegiline drugs, their trade names, available forms, doses and also pharmaceutical companies - manufacturers, distributors and suppliers, researchers and developers:
|Trade name of the drug
||Pharmaceutical forms and doses
||Tablets; Oral; Selegiline Hydrochloride 5 mg
||Capsules; Oral; Selegiline Hydrochloride 5 mgSyrup; Oral; Selegiline Hydrochloride 10 mg / 5 mlTablets; Oral; Selegiline Hydrochloride 5 mgTablets; Oral; Selegiline Hydrochloride 10 mg
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||Transdermal Systems; Topical; Selegiline 6 mg / 24 hTransdermal Systems; Topical; Selegiline 9 mg / 24 hTransdermal Systems; Topical; Selegiline 12 mg / 24 h
||MylanBristol-Myers SquibbSomerset Pharmaceuticals
||Tablets; Oral; Selegiline Hydrochloride 5 mg
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