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Eldepryl, Emsam, Deprenyl (Selegiline HCl)Selegiline (trade names include Deprenyl; Eldepryl; Emsam; Egibren; Selegilin; Jumex; Jumexil; Zelapar; Niar; Plurimen; Selegos; Selgin) is a monoamine oxidase type B (MAO-B) inhibitor. This medication is the only anti-Parkinson's agent that has been found to slow the loss of dopamine, which is responsible for therapeutic effect in Parkinson's disease. Selegiline HCl is often used with levodopa and carbidopa in the treatment of Parkinson's disease because it increases and extends effects of levodopa, and may help to slow the progress of parkinsonism. This medicine is usually added to the therapy when there is a decrease in response to levodopa.

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Pharmaceutical forms and dosages:
  • Eldepryl (Selegiline) 5 mg tablets
  • Eldepryl (Selegiline) 10 mg tablets
  • Deprenyl, Eldepryl (Selegiline) 5 mg tablets
  • Selegiline Hydrochloride (Eldepryl generic) 5 mg tablets
  • Emsam 5 mg tablets
  • Eldepryl 5 mg tablets
  • Quantity in a package:
  • Eldepryl (Selegiline) 5 mg: 30, 60, 90, 120, 180, 240, 360 pills
  • Eldepryl (Selegiline) 10 mg: 30, 60, 90, 120, 240 pills
  • Deprenyl, Eldepryl (Selegiline HCl) 5 mg: 30, 60, 90, 180 pills
  • Selegiline (Eldepryl generic) 5 mg: 30, 60, 90, 120, 180, 360 pills
  • Emsam 5 mg: 30, 60, 90 pills
  • Eldepryl 5 mg: 60, 90 pills
  • Type of Selegiline - brand / generic:
  • Eldepryl (Selegiline) generic
  • Selegiline generic
  • Deprenyl generic
  • Eldepryl generic
  • Eldepryl (Selegiline HCl) generic
  • Emsam generic
  • Eldepryl generic
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    There is an additional general information about Selegiline (Deprenyl, Eldepryl, Emsam):

    Medical and pharmaceutical categories for selegiline:

  • Pharmaceutical drugs for the treatment of Parkinson's disease
  • Central nervous system agents
  • Monoamine oxidase B (MAO-B) inhibitors
  • Veterinary medications; pet meds

    The Anatomical Therapeutic Chemical (ATC) classification system selegiline codes:

  • N - Nervous system
  • N04 - Anti-parkinson drugs
  • N04B - Dopaminergic agents
  • N04BD - Monoamine oxidase B inhibitors
  • N04BD01 - Selegiline

    Selegiline in The International Statistical Classification of Diseases and Related Health Problems (ICD-10, World Health Organization) codes:

  • Dementia in Alzheimer's disease ( G30.-+ ) - F00*
  • Parkinson's disease - G20
    Paralysis agitans
    Parkinsonism or Parkinson's disease:
    - NOS
    - idiopathic
    - primary

    Pregnancy and breastfeeding categories for Selegiline (Eldepryl, Deprenyl):

  • C - Australia
  • C - United States (Risk cannot be ruled out)

    Salts and other selegiline forms used as active pharmaceutical ingredients (API):

  • Selegiline Base
  • Selegiline Citrate
  • Selegiline Hydrochloride

    Synonyms of selegiline, international and chemical names:

  • (-)-Deprenil
  • (R)-(-)-N,alpha-Dimethyl-N-2-propinylphenethylamine
  • (R)-(-)-N-Methyl-N-(1-phenyl-2-propyl)-2-propinylamin
  • Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-, (R)-
  • Deprenil
  • Deprenyl
  • L-Deprenalin
  • Selegelin
  • Selegeline
  • Selegiliini
  • Selegilin
  • Selegilin Hydrochlorid
  • Selegilina
  • Selegiline HCl
  • Selegilinum
  • Szelegilin

    Best known selegiline brands, generics and trade names in various countries:

  • Anipryl - Pfizer
  • Apo-Selegiline - Apotex
  • Cognitive - Ebewe Pharma
  • Deprenyl - Sanofi-Aventis; HRA Pharma; Orion Pharma
  • Deprilan - Biosintetica Laboratorios
  • Egibren - Chiesi
  • Eldepryl - Genepharm; Allphar Services; Deprenyl Research; Douglas Pharmaceuticals; Draxis Health; Orion Pharma; Reckitt Benckiser; Somerset Pharmaceuticals; Themis Medicare; Viatris
  • Elepril - Americano de Farmacoterapia Laboratorio
  • Emsam - Bristol-Myers Squibb; Somerset Pharmaceuticals
  • Jumex - Sanofi-Aventis; Chiesi; Chinoin Pharmaceutical and Chemical Works; Dexxon; DKSH; IDS Group; IVAX; Metro Drug Distribution; Novartis; The Glory Medicina; Zuellig Pharma
  • Jumexil - Farmalab Industrias Quimicas e Farmaceuticas
  • Kinabide - Bago Laboratorios
  • Movergan - Orion Pharma
  • Niar - Abbott; Knoll
  • Otrasel - Cephalon; Lafon Laboratoires
  • Plurimen - Viatris
  • Sefmex - Unison Laboratories; Firma Welfare Instrument; Health Alliance International; Medispec
  • Segan - Polpharma
  • Selegilin - Azupharma; CT-Arzneimittel; Helvepharm; Mepha; Ratiopharm; Stada; Teva
  • Selegiline - Alphapharm; Biogaran; Clonmel Healthcare; IVAX; Merck; Mylan; Pro Doc; Sandoz; Teva
  • Selegos - Medochemie; Derek Marketing; Komedic; Star Medical Supplies
  • Selerin - Cipla
  • Selgene - Merck; Alphapharm; Pacific Pharmaceuticals
  • Selgin - Intas Pharmaceuticals
  • Zelapar - Cephalon; Cardinal Health; Valeant Pharmaceuticals; Zeneus Pharma

    Some other medications in Deprenyl, Eldepryl and Emsam (Selegiline) pharmacological classes:

  • Almirid (Dihydroergocryptine Mesylate)
  • Aricept (Donepezil)
  • Artane (Trihexyphenidyl)
  • Azilect (Rasagiline)
  • Comtan (Entacapone)
  • Dostinex (Cabergoline)
  • Exelon (Rivastigimine)
  • Kemadrin (Procyclidine)
  • Larodopa (Levodopa)
  • Mirapex (Pramipexole)
  • Namenda (Memantine)
  • Neupro (Rotigotine)
  • Nootropil (Piracetam)
  • Parlodel (Bromocriptine)
  • Parkinsan (Budipine)
  • Permax (Pergolide)
  • Reminyl (Galantamine)
  • Requip (Ropinirole)
  • Sinemet, Sinemet CR (Carbidopa; Levodopa)
  • Stalevo (Carbidopa; Entacapone; Levodopa)
  • Symmetrel (Amantadine)
  • Taluvian (Apomorphine)
  • Tasmar (Tolcapone)
  • Trivastal (Piribedil)


    What is Selegiline, generic Eldepryl and Deprenyl?

    Selegiline prevents the breakdown of a chemical in your brain called dopamine. Low levels of this chemical are associated with Parkinson's disease.
    Eldepryl is used together with other medicines to treat symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control. Selegiline oral is also used to treat similar muscle symptoms when they are caused by certain medicines, including chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), and others.
    This medication may also be used for purposes other than those listed in this medication guide.

    Selegiline (Eldepryl; Deprenyl) indications and usage

    Eldepryl and Deprenyl (Selegiline HCl) is indicated as an adjunct in the management of Parkinsonian patients being treated with levodopa/carbidopa who exhibit deterioration in the quality of their response to this therapy. There is no evidence from controlled studies that selegiline has any beneficial effect in the absence of concurrent levodopa therapy.

    Evidence supporting this claim was obtained in randomized controlled clinical investigations that compared the effects of added selegiline or placebo in patients receiving levodopa/carbidopa. Selegiline was significantly superior to placebo on all three principal outcome measures employed: change from baseline in daily levodopa/carbidopa dose, the amount of 'off' time, and patient self-rating of treatment success. Beneficial effects were also observed on other measures of treatment success (e.g., measures of reduced end of dose akinesia, decreased tremor and sialorrhea, improved speech and dressing ability and improved overall disability as assessed by walking and comparison to previous state).

    Side effects of selegiline

    The common side effects reported with Eldepryl are increased tremor, chorea, loss of balance, restlessness, blepharospasm, increased bradykinesia, tardive dyskinesia, dystonic symptoms, dyskinesia, involuntary movements, freezing, festination, hallucinations, dizziness, confusion, anxiety, depression, drowsiness, behavior/mood change, headache, back pain, leg pain, tinnitus, migraine, supraorbital pain, throat burning, orthostatic hypotension, hypertension, arrhythmia, palpitations, new or increased angina pectoris, nausea/vomiting, constipation, weight loss, anorexia, poor appetite, dysphagia and diarrhea.

    Guidelines before using Selegiline Hydrochloride (Deprenyl; Eldepryl) generic

  • Do not use Eldepryl if you are also taking meperidine (Demerol).
  • Before using this medication, tell your doctor if you have heart disease, seizures, or dizzy spells.
  • If you need to have surgery, tell the surgeon that you are using selegiline. You may need to briefly stop using the medicine before your surgery.
  • FDA pregnancy category C. This drug may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
  • It is not known whether selegiline hydrochloride passes into breast milk or if it could harm a nursing baby. Do not take Eldepryl without telling your doctor if you are breast-feeding a baby.

    What are the common dosages of this medication?

    Deprenyl and Eldepryl (Selegiline Hydrochloride) is intended for administration to Parkinsonian patients receiving levodopa/carbidopa therapy who demonstrate a deteriorating response to this treatment. The recommended regimen for the administration of Eldepryl (Selegiline HCl) is 10 mg per day administered as divided doses of 5 mg each taken at breakfast and lunch. There is no evidence that additional benefit will be obtained from the administration of higher doses. Moreover, higher doses should ordinarily be avoided because of the increased risk of side effects.

    After two to three days of selegiline treatment, an attempt may be made to reduce the dose of levodopa/carbidopa. A reduction of 10 to 30% was achieved with the typical participant in the domestic placebo controlled trials who was assigned to selegiline treatment. Further reductions of levodopa/carbidopa may be possible during continued selegiline therapy.

    How should I take Selegiline Hydrochloride (Eldepryl; Deprenyl)?

  • Take this medicine by mouth with a glass of water. Take your doses at regular intervals. Do not take selegiline more often than directed. Do not stop taking except on the advice of your doctor or health care professional.
  • Talk to your pediatrician regarding the use of this drug in children. Special care may be needed.
  • Note: This medication is only for you. Do not share this medicine with others.

    What if I miss a dose?

    If you miss a dose of selegiline, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

    What happens if I overdose?

  • If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
  • Symptoms of selegiline overdose may include excitement, irritability, nervousness, insomnia, dizziness, severe headache, hallucinations, sweating, light-headedness, fainting, or seizures.

    What may interact with this medicine?

    Do not use Eldepryl or Deprenyl if you are also taking meperidine (Demerol).
    Before using selegiline, tell your doctor if you are using any of the following drugs:
  • antidepressants such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), paroxetine (Paxil), or sertraline (Zoloft);
  • antidepressants such as amitriptyline (Elavil), nortriptyline (Pamelor), desipramine (Norpramin), or imipramine (Tofranil);
  • St. John's wort;
  • cyclobenzaprine (Flexeril);
  • carbamazepine (Tegretol) or oxcarbazepine (Trileptal);
  • buspirone (Buspar);
  • cold or cough medicine; or
  • diet pills or stimulants.
    If you are using any of these drugs, you may not be able to take selegiline, or you may need dosage adjustments or special tests during treatment.
    This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

    Where should I keep selegiline tablets or capsules?

    Keep out of the reach of children.
    Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

    What is the difference between brand and generic Selegiline (Eldepryl, Deprenyl)?

    Brand and generic Eldepryl in oral capsules and tablets contains "selegiline hydrochloride" as the active ingredient and hence the mechanism of action is the same. The difference between brand and generic forms are packaging, pricing and the brand name. Generic variants are priced cheaper because there are no brand names associated with it as well as no expenses towards research and development. You can buy cheap selegiline medicine when it is sold as a generic variant.

    Where and how to buy Deprenyl; Eldepryl / Generic Selegiline online?

    You can buy eldepryl or deprenyl online, order or purchase selegiline medication from one of trusted online pharmacies, the list and review of which you can find above on this webpage. When you order selegiline drug online from this qualitative drugstores, it will reach your doorstep without any hassles. You can also save more when you buy selegiline online in more numbers with the volume discounts these pharma shops offer.

    Why is the price of Selegiline (Generic Deprenyl and Eldepryl) so cheap at "Medicines Store", "Discount Meds", "Drugs for Health" and "Cheap Meds for Sale" online pharmacies?

    This certified online pharmacies sell selegiline, which is priced lesser compared to brands because of the savings in research and development of the drug. Generic drugs do not require any spending on research and development activities. They also source all drugs directly from the manufacturers thereby eliminating any additional costs such as commissions to agents etc. All the savings accrued through various measures translates to the cheaper price of drugs at these online drugstores. You can also get additional price benefits by taking advantage of the volume discounts they offer.

    Here is a list of some medications containing "Selegiline" as a main active pharmaceutical ingredient (API) of selegiline drugs, their trade names, available forms, doses and also pharmaceutical companies - manufacturers, distributors and suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
  • Tablets; Oral; Selegiline Hydrochloride 5 mg
  • Sanofi-Aventis
  • Egibren
  • Tablets; Oral; Selegiline Hydrochloride 5 mg
  • Tablets; Oral; Selegiline Hydrochloride 10 mg
  • Chiesi
  • Eldepryl
  • Capsules; Oral; Selegiline Hydrochloride 5 mg
  • Tablets; Oral; Selegiline Hydrochloride 5 mg
  • Tablets; Oral; Selegiline Hydrochloride 10 mg
  • Genepharm
  • Allphar Services
  • Aspen
  • Deprenyl Research
  • Douglas Pharmaceuticals
  • Draxis Health
  • Orion Pharma
  • Reckitt Benckiser
  • Somerset Pharmaceuticals
  • Themis Medicare
  • Viatris
  • Emsam
  • Transdermal Systems; Topical; Selegiline 12 mg / 24 h
  • Transdermal Systems; Topical; Selegiline 6 mg / 24 h
  • Transdermal Systems; Topical; Selegiline 9 mg / 24 h
  • Bristol-Myers Squibb
  • Somerset Pharmaceuticals
  • Jumex
  • Tablets; Oral; Selegiline Hydrochloride 5 mg
  • Sanofi-Aventis
  • Chiesi
  • Chinoin Pharmaceutical and Chemical Works
  • Dexxon
  • DKSH
  • IDS Group
  • IVAX
  • Metro Drug Distribution
  • Novartis
  • The Glory Medicina
  • Zuellig Pharma
  • Niar
  • Tablets; Oral; Selegiline Hydrochloride 5 mg
  • Abbott
  • Knoll
  • Plurimen
  • Tablets; Oral; Selegiline Hydrochloride 5 mg
  • Viatris
  • Selegilin
  • Tablets; Oral; Selegiline Hydrochloride 10 mg
  • Tablets; Oral; Selegiline Hydrochloride 5 mg
  • Ratiopharm
  • Selgin
  • Tablets; Oral; Selegiline Hydrochloride 5 mg
  • Intas Pharmaceuticals
  • Zelapar
  • Tablets, Orally Disintegrating; Oral; Selegiline Hydrochloride 1.25 mg
  • Cephalon
  • Cardinal Health
  • Valeant Pharmaceuticals
  • Zeneus Pharma

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